Partial load-bearing rabbit ulnar segmental defects are regenerated with biocompatible grafts with or without bone marrow-derived mesenchymal stem cells.

Content Provider	Europe PMC
Author	Basaran, Serdar Hakan Bayrak, Alkan Tanrıverdi, Gamze Tanriverdi, Bülent Avkan, Mustafa Cevdet
Copyright Year	2022
Abstract	ABSTRACTBACKGROUND:The autologous bone grafts still have been used as the gold standard to initiate and facilitate bone healing in cases with bone defects. Because of some disadvantages of autologous bone grafts, the new biocomposite grafts have been researched. The purpose of the present study was to investigate whether the bone marrow-derived mesenchymal stem cells (BM-MSCs) loaded into a biocomposite scaffold enhance bone regeneration.METHODS:In our study, a 10 mm osteoperiosteal segmental bone defect was created in the middle of the right and left ulnar bones of eight rabbits. The created defects were filled in the right ulnar bones of eight rabbits (Group I) with BM-MSCs loaded onto a biocomposite scaffold (Plexur PTM, Osteotech, Eatontown, NJ, USA) and in the other ulnar bones of the same rabbits (Group II) with only biocomposite graft. Radiographs of each forelimb were taken postoperatively at the end of the 6th week. Then, the rabbits were euthanized pharmacologically for histopathological evaluation.RESULTS:Were scored using a modified Lane and Sandhu scoring system. All defects healed in both groups. Radiological and histological total scores were slightly better in Group I, but statistical tests did not reveal any significant differences between the two groups at the end of the 6th week radiologically and histologically (p>0.05).CONCLUSION:The results of our study demonstrated that in rabbit ulnar segmental bone defect model was obtained satisfactory regeneration with using biocomposite graft with or without BM-MSCs.
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ISSN	1306696X
Journal	Turkish Journal of Trauma & Emergency Surgery [Ulus Travma Acil Cerrahi Derg]
Volume Number	28
DOI	10.14744/tjtes.2021.64569
PubMed Central reference number	PMC10315982
Issue Number	8
PubMed reference number	35920424
e-ISSN	13077945
Language	English
Publisher	Kare Publishing
Publisher Date	2022-08-01
Publisher Place	Turkey
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Copyright © 2022 Turkish Journal of Trauma and Emergency Surgery
Subject Keyword	Bone regeneration bone scaffold bone tissue engineering mesenchymal stem cells rabbit segmental bone defect
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine Surgery Anesthesiology and Pain Medicine