NDLI: Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.

Please wait, while we are loading the content...

Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.

Content Provider	Europe PMC
Author	Docherty, JamieH. Lister, Thomas M. Mcarthur, Gillian Findlay, Michael T. Domingo-Legarda, Pablo Kenyon, Jacob Choudhary, Shweta Larrosa, Igor
Copyright Year	2023
Abstract	Site-predictable and chemoselective C–H bond functionalizationreactions offer synthetically powerful strategies for the step-economicdiversification of both feedstock and fine chemicals. Many transition-metal-catalyzedmethods have emerged for the selective activation and functionalizationof C–H bonds. However, challenges of regio- and chemoselectivityhave emerged with application to highly complex molecules bearingsignificant functional group density and diversity. As molecular complexityincreases within molecular structures the risks of catalyst intoleranceand limited applicability grow with the number of functional groupsand potentially Lewis basic heteroatoms. Given the abundance of C–Hbonds within highly complex and already diversified molecules suchas pharmaceuticals, natural products, and materials, design and selectionof reaction conditions and tolerant catalysts has proved criticalfor successful direct functionalization. As such, innovations withintransition-metal-catalyzed C–H bond functionalization for thedirect formation of carbon–carbon bonds have been discoveredand developed to overcome these challenges and limitations. This reviewhighlights progress made for the direct metal-catalyzed C–Cbond forming reactions including alkylation, methylation, arylation,and olefination of C–H bonds within complex targets.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10311463&blobtype=pdf
ISSN	00092665
Journal	Chemical Reviews [Chem Rev]
Volume Number	123
DOI	10.1021/acs.chemrev.2c00888
PubMed Central reference number	PMC10311463
Issue Number	12
PubMed reference number	37163671
e-ISSN	15206890
Language	English
Publisher	American Chemical Society
Publisher Date	2023-05-10
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2023 The Authors. Published by American Chemical Society
Content Type	Text
Resource Type	Article
Subject	Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in