Prevalence and Correlates of Comorbid Posttraumatic Stress Disorder in Schizophrenia-Spectrum Disorder: A Systematic Review and Meta-Analysis.

Content Provider	Europe PMC
Author	Seong, Anna Cho, Seo-Eun Na, Kyoung-Sae
Copyright Year	2023
Abstract	ObjectiveSchizophrenia-spectrum disorders and posttraumatic stress disorder (PTSD) share common clinical manifestations, genetic vulnerability, and environmental risk factors. We aimed to conduct a systematic review and meta-analysis of the comorbid prevalence of PTSD among schizophrenia-spectrum disorders.MethodsWe performed a meta-analysis to identify possible contributing factors to the heterogeneity among these studies. We systematically searched electronic databases with no restrictions on language of articles.ResultsWe extracted 24 samples (18 for current prevalence and 6 for lifetime prevalence) from 22 studies and used a random effects model to estimate the pooled prevalence of PTSD among schizophrenia-spectrum disorders. The current and life prevalence of comorbid PTSD was 10.6% (95% confidence interval [CI]=6.3%–17.3%) and 13.0% (95% CI=5.3%–28.6%), respectively. Studies assessing psychotic experiences/involuntary admission reported the highest prevalence of comorbid PTSD (57.1%, 95% CI=43.6%–59.7%), whereas those assessing various anxiety disorders reported the lowest prevalence (1.1%, 95% CI=1.0%–5.5%). Heterogeneities of the subgroup analysis by similar objectives were largely homogeneous (I2=7.1–34.1). In the qualitative assessment, only two studies (9.1%) were evaluated as having a low risk of bias.ConclusionOur results showed that a careful approach with particular attention to assessing PTSD is essential to reliably estimate the prevalence of PTSD comorbid with schizophrenia-spectrum disorders. The reason for the wide discrepancy in the prevalence of comorbid PTSD among the four groups of studies should be addressed in future research.
ISSN	17383684
Journal	Psychiatry Investigation
Volume Number	20
PubMed Central reference number	PMC10307913
Issue Number	6
PubMed reference number	37248688
e-ISSN	19763026
DOI	10.30773/pi.2022.0353
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2023-05-30
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2023 Korean Neuropsychiatric Association
Subject Keyword	Schizophrenia Posttraumatic stress disorder Meta-analysis Systematic review Prevalence
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health