NDLI: Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice.

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Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice.

Content Provider	Europe PMC
Author	Gao, Bei Chen, Lixia Xu, Weichen Shan, Jinjun Shen, Weishou Gao, Nan
Editor	Meyer, Markus R.
Copyright Year	2023
Abstract	Perfluorooctanoic acid (PFOA) represents an increasing public health concern due to its persistence in the environment and its toxic effects. The gut microbiota is known to produce various metabolites that assist the host to maintain metabolic homeostasis. However, few studies have explored the effects of PFOA on gut-microbiota-related metabolites. In the present study, male C57BL/6J mice were exposed to 1 ppm of PFOA in drinking water for four weeks and integrative analysis of the gut microbiome and metabolome was performed to reveal the health effects of PFOA. Our results showed that PFOA disturbed both the gut microbiota composition and the metabolic profiles of the feces, serum, and liver in mice. A correlation was found between Lachnospiraceae UCG004, Turicibacter, Ruminococcaceae, and different fecal metabolites. Significant alterations of gut-microbiota-related metabolites were induced by PFOA exposure, including bile acids and tryptophan metabolites such as 3-indoleacrylic acid and 3-indoleacetic acid. The findings of this study are helpful to improve the understanding of the health effects of PFOA, which might be mediated through the gut microbiota and its related metabolites.
Volume Number	13
PubMed Central reference number	PMC10305235
Issue Number	6
PubMed reference number	37367865
Journal	Metabolites
e-ISSN	22181989
DOI	10.3390/metabo13060707
Language	English
Publisher	MDPI
Publisher Date	2023-05-30
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	gut microbiome tryptophan derivatives glycodeoxycholic acid beta-hyodeoxycholic acid gamma-muricholic acid
Content Type	Text
Resource Type	Article
Subject	Biochemistry Endocrinology, Diabetes and Metabolism Molecular Biology

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