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Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia.
| Content Provider | Europe PMC |
|---|---|
| Author | Harima, Hayato Qiu, Yongjin Yamagishi, Junya Kajihara, Masahiro Changula, Katendi Okuya, Kosuke Isono, Mao Yamaguchi, Tomoyuki Ogawa, Hirohito Nao, Naganori Sasaki, Michihito Simulundu, Edgar Mweene, Aaron S. Sawa, Hirofumi Ishihara, Kanako Hang’ombe, Bernard M. Takada, Ayato |
| Editor | Woo, Patrick C.Y. Li, Kenneth |
| Copyright Year | 2023 |
| Abstract | Bats are of significant interest as reservoirs for various zoonotic viruses with high diversity. During the past two decades, many herpesviruses have been identified in various bats worldwide by genetic approaches, whereas there have been few reports on the isolation of infectious herpesviruses. Herein, we report the prevalence of herpesvirus infection of bats captured in Zambia and genetic characterization of novel gammaherpesviruses isolated from striped leaf-nosed bats (Macronycteris vittatus). By our PCR screening, herpesvirus DNA polymerase (DPOL) genes were detected in 29.2% (7/24) of Egyptian fruit bats (Rousettus aegyptiacus), 78.1% (82/105) of Macronycteris vittatus, and one Sundevall’s roundleaf bat (Hipposideros caffer) in Zambia. Phylogenetic analyses of the detected partial DPOL genes revealed that the Zambian bat herpesviruses were divided into seven betaherpesvirus groups and five gammaherpesvirus groups. Two infectious strains of a novel gammaherpesvirus, tentatively named Macronycteris gammaherpesvirus 1 (MaGHV1), were successfully isolated from Macronycteris vittatus bats, and their complete genomes were sequenced. The genome of MaGHV1 encoded 79 open reading frames, and phylogenic analyses of the DNA polymerase and glycoprotein B demonstrated that MaGHV1 formed an independent lineage sharing a common origin with other bat-derived gammaherpesviruses. Our findings provide new information regarding the genetic diversity of herpesviruses maintained in African bats. |
| Journal | Viruses |
| Volume Number | 15 |
| PubMed Central reference number | PMC10303238 |
| Issue Number | 6 |
| PubMed reference number | 37376669 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v15061369 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-06-13 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | herpesvirus bat surveillance complete genome Zambia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology |
