Anaplasma phagocytophilum Community-Acquired Pneumonia: Case Report and Literature Review.

Content Provider	Europe PMC
Author	Dumic, Igor Person, Emily Igandan, Oladapo Adetimehin, Omobolanle Nordstrom, Charles W. Williams, Christopher Shweta, Fnu
Editor	Espinoza, Jorge Luis
Copyright Year	2023
Abstract	Anaplasma phagocytophilum is an emerging, Gram-negative, and obligate intracellular pathogen that is infrequently implicated as a causative agent of community-acquired pneumonia. In this paper, we report about an immunocompetent patient from the community who presented with fever, cough, and shortness of breath. Chest X-ray and CT showed bilateral lung infiltrates. Extensive workup for other common and uncommon causes of pneumonia was positive for anaplasmosis. The patient recovered completely with doxycycline therapy. In our literature review, we find that in 80% of reported cases of anaplasmosis pneumonia, empiric treatment did not contain doxycycline, which in some cases led to acute respiratory distress syndrome. Clinicians in tick-borne disease endemic regions should be aware of this unusual presentation of anaplasmosis in order to be able to select appropriate antimicrobial regimens and initiate timely management.
Journal	Microorganisms
Volume Number	11
PubMed Central reference number	PMC10302541
Issue Number	6
PubMed reference number	37374985
e-ISSN	20762607
DOI	10.3390/microorganisms11061483
Language	English
Publisher	MDPI
Publisher Date	2023-06-02
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	pneumonia pneumonitis Anaplasma phagocytophilum Lyme disease tick-borne diseases
Content Type	Text
Resource Type	Article
Subject	Microbiology Microbiology (medical) Virology