NDLI: Electrospun Drug-Loaded and Gene-Loaded Nanofibres: The Holy Grail of Glioblastoma Therapy?

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Electrospun Drug-Loaded and Gene-Loaded Nanofibres: The Holy Grail of Glioblastoma Therapy?

Content Provider	Europe PMC
Author	Louis, Lynn Chee, Bor shin McAfee, Marion Nugent, Michael
Editor	Etrych, Tomáš
Copyright Year	2023
Abstract	To date, GBM remains highly resistant to therapies that have shown promising effects in other cancers. Therefore, the goal is to take down the shield that these tumours are using to protect themselves and proliferate unchecked, regardless of the advent of diverse therapies. To overcome the limitations of conventional therapy, the use of electrospun nanofibres encapsulated with either a drug or gene has been extensively researched. The aim of this intelligent biomaterial is to achieve a timely release of encapsulated therapy to exert the maximal therapeutic effect simultaneously eliminating dose-limiting toxicities and activating the innate immune response to prevent tumour recurrence. This review article is focused on the developing field of electrospinning and aims to describe the different types of electrospinning techniques in biomedical applications. Each technique describes how not all drugs or genes can be electrospun with any method; their physico-chemical properties, site of action, polymer characteristics and the desired drug or gene release rate determine the strategy used. Finally, we discuss the challenges and future perspectives associated with GBM therapy.
Journal	Pharmaceutics
Volume Number	15
PubMed Central reference number	PMC10302184
Issue Number	6
PubMed reference number	37376095
e-ISSN	19994923
DOI	10.3390/pharmaceutics15061649
Language	English
Publisher	MDPI
Publisher Date	2023-06-03
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	electrospun nanofibres glioblastoma (GBM) electrospinning
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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