NDLI: Neonatal Abstinence Syndrome in Infants with Prenatal Exposure to Methadone versus Buprenorphine.

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Neonatal Abstinence Syndrome in Infants with Prenatal Exposure to Methadone versus Buprenorphine.

Content Provider	Europe PMC
Author	Kushnir, Alla Bhavsar, Ravi Hanna, Emad Hegyi, Thomas
Editor	Hayes, Marie J.
Copyright Year	2023
Abstract	Neonatal abstinence syndrome (NAS) has been of increasing concern. Studies suggest that prenatal exposure to buprenorphine may be preferred to methadone in regard to neonatal withdrawal. Our aim was to determine whether the incidence and severity of NAS are different between babies prenatally exposed to methadone or buprenorphine in pregnancy. This retrospective analysis of infants ≥ 35-weeks-old exposed to methadone/buprenorphine alone or in conjunction with other substances in utero. They were divided into four groups: 1—methadone alone (Met), 2—buprenorphine alone (Bup), 3 and 4—those exposed to methadone and buprenorphine, respectively, in conjunction with other drugs (Met+ and Bup+). The frequency of NAS treatment, duration of treatment (LOT) and length of stay (LOS) were compared between groups. Of the 290 mothers, 59% were in the Met group, 18% in the Bup group, 14% in the Met or Bup and another opiate group, and 9% took methadone or buprenorphine plus various other substances. Infants born to Met/Met+ mothers had a four-times higher likelihood of developing NAS (p < 0.001). There was no difference in the LOS (p = 0.08) or LOT (p = 0.11) between groups. The buprenorphine treatment in pregnancy decreased the risk of babies developing NAS. However, once the NAS required pharmacological treatment, the type of maternal prenatal exposure did not affect the LOS or LOT.
Volume Number	10
PubMed Central reference number	PMC10297113
Issue Number	6
PubMed reference number	37371262
Journal	Children (Basel)
e-ISSN	22279067
DOI	10.3390/children10061030
Language	English
Publisher	MDPI
Publisher Date	2023-06-08
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	neonatal abstinence syndrome (NAS) opioids methadone buprenorphine outcomes length of treatment
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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