NDLI: A Novel Aggregation-Induced Emission Fluorescent Probe for Detection of β-Amyloid Based on Pyridinyltriphenylamine and Quinoline-Malononitrile.

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A Novel Aggregation-Induced Emission Fluorescent Probe for Detection of β-Amyloid Based on Pyridinyltriphenylamine and Quinoline-Malononitrile.

Content Provider	Europe PMC
Author	Fang, Yan Wang, Qi Xiang, Chenlong Liu, Guijin Li, Junjian
Copyright Year	2023
Abstract	β-amyloid is an important pathological feature of Alzheimer’s disease. Its abnormal production and aggregation in the patient’s brain is an important basis for the early diagnosis and confirmation of Alzheimer’s disease. In this study, a novel aggregation-induced emission fluorescent probe, PTPA-QM, was designed and synthesized based on pyridinyltriphenylamine and quinoline–malononitrile. These molecules exhibit a donor–donor–π–acceptor structure with a distorted intramolecular charge transfer feature. PTPA-QM displayed the advantages of good selectivity toward viscosity. The fluorescence intensity of PTPA-QM in 99% glycerol solution was 22-fold higher than that in pure DMSO. PTPA-QM has been confirmed to have excellent membrane permeability and low toxicity. More importantly, PTPA-QM exhibits a high affinity towards β-amyloid in brain sections of 5XFAD mice and classical inflammatory cognitive impairment mice. In conclusion, our work provides a promising tool for the detection of β-amyloid.
Volume Number	13
PubMed Central reference number	PMC10296659
Issue Number	6
PubMed reference number	37366974
Journal	Biosensors (Basel)
e-ISSN	20796374
DOI	10.3390/bios13060610
Language	English
Publisher	MDPI
Publisher Date	2023-06-02
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	aggregation-induced emission fluorescent probe β-amyloid viscosity Alzheimer’s disease
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry Instrumentation Medicine Biomedical Engineering Engineering Analytical Chemistry Biotechnology

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