NDLI: Targeting B Cell Maturation Antigen in Patients with Multiple Myeloma: Current Perspectives.

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Targeting B Cell Maturation Antigen in Patients with Multiple Myeloma: Current Perspectives.

Content Provider	Europe PMC
Author	Shrivastava, Trilok Van Rhee, Frits Al Hadidi, Samer
Copyright Year	2023
Abstract	AbstractRelapsed/refractory multiple myeloma remains a challenging disease necessitating the development of more effective treatment options. In the past decade, myeloma therapies have made significant advancements with the introduction of new treatment modalities. One of the new major targets for these novel therapeutics has been B-cell maturation antigen (BCMA), which is expressed on mature B-lymphocytes and plasma cells. There are three main categories of BCMA-targeted therapies currently available, including bispecific antibodies (BsAbs), antibody drug conjugates (ADCs), and chimeric antigen receptor (CAR) T-cell therapies. In this review, we discuss the existing BCMA-targeted therapies and provide insights into currently available treatment and future developments, with a particular focus on clinical efficacy and common drug-related adverse events.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10290473&blobtype=pdf
Page Count	24
Journal	OncoTargets and Therapy [Onco Targets Ther]
Volume Number	16
PubMed Central reference number	PMC10290473
PubMed reference number	37359353
e-ISSN	11786930
DOI	10.2147/ott.s370880
Language	English
Publisher	Dove
Publisher Date	2023-06-20
Access Restriction	Open
Rights License	This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2023 Shrivastava et al.
Subject Keyword	BCMA multiple myeloma bispecific antibody BiTE CAR T cells B-cell maturation antigen
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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