Differential Aspects of Natural and Morphine Reward-related Behaviors in Conditioned Place Preference Paradigm.

Content Provider	Europe PMC
Author	Jamali, Shole Aliyari Shoorehdeli, Mahdi Daliri, Mohammad Reza Haghparast, Abbas
Copyright Year	2022
Abstract	Introduction:Natural rewards are essential for survival. However, drug-seeking behaviors can be maladaptive and endanger survival. The present study was conducted to enhance our understanding of how animals respond to food and morphine as natural and drug rewards, respectively, in a conditioned place preference (CPP) paradigm.Methods:We designed a protocol to induce food CPP and compare it as a natural reward with morphine CPP in rats. The protocol for reward induction in both groups (foods and morphine) consisted of three phases: pre-test, conditioning, and post-test. In morphine groups, we injected morphine as a reward (5 mg/kg, SC). To induce natural reward, we used two different protocols. In the first one, the rats were deprived of food for 24 h. In the other method, the rats were restricted to food for 14 days. During the conditioning period, the animals received daily chow, biscuits, or popcorn as a reward inducer.Results:Results revealed that CPP was not induced in food-deprived rats. A combination of food restriction (as a facilitator) and a biscuit or popcorn-induced reward using CPP. In contrast, food deprivation did not facilitate food CPP in response to regular food. Interestingly the CPP score of the group which received biscuits during a 7-day conditioning period was more than that of the morphine group.Conclusion:In conclusion, food restriction could be a better protocol than food deprivation to facilitate food reward.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10258599&blobtype=pdf
ISSN	2008126X
Journal	Basic and Clinical Neuroscience [Basic Clin Neurosci]
Volume Number	13
DOI	10.32598/bcn.2021.3071.1
PubMed Central reference number	PMC10258599
Issue Number	5
PubMed reference number	37313024
e-ISSN	22287442
Language	English
Publisher	Tehran University of Medical Sciences
Publisher Date	2022-09-01
Access Restriction	Open
Rights License	This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Copyright© 2022 Iranian Neuroscience Society
Subject Keyword	Natural reward Morphine reward Food deprivation Food restriction Conditioned place preference Rat
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience