NDLI: Chemical Constituents, Enantiomer Content, Antioxidant and Anticholinesterase Activities of <i>Valeriana microphylla</i> Kunth Essential Oil.

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Chemical Constituents, Enantiomer Content, Antioxidant and Anticholinesterase Activities of Valeriana microphylla Kunth Essential Oil.

Content Provider	Europe PMC
Author	Aguilar, Gabriela Calva, James Cartuche, Luis Salinas, Melissa Armijos, Chabaco
Editor	Palá-Pául, Jésus Brophy, Joe
Copyright Year	2023
Abstract	The study of the essential oil (EO) from aerial parts (stems and leaves) of Valeriana microphylla Kunth (Valerianaceae), collected from the Saraguro community in the southern region of Ecuador, was analyzed for the first time. A total of 62 compounds were identified in V. microphylla EO by GC-FID and GC-MS on nonpolar DB-5ms and polar HP-INNOWax columns. The most abundant components (>5%) detected on DB-5ms and polar HP-INNOWax columns were α-gurjunene (11.98, 12.74%), germacrene D (11.47, 14.93%), E-caryophyllene (7.05, 7.78%), and α-copaene (6.76, 6.91%), respectively. In addition, the enantioselective analysis, carried out on a chiral column, showed (+)-α-pinene and (R)-(+)-germacrene as enantiomerically pure compounds (enantiomeric excess = 100%). The antioxidant activity was high for the radicals ABTS (SC50 = 41.82 µg/mL) and DPPH (SC50 = 89.60 µg/mL), and finally, the EO was shown to be inactive to the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as both values were >250 µg/mL.
Journal	Plants (Basel, Switzerland)
Volume Number	12
PubMed Central reference number	PMC10255249
Issue Number	11
PubMed reference number	37299143
e-ISSN	22237747
DOI	10.3390/plants12112155
Language	English
Publisher	MDPI
Publisher Date	2023-05-30
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	Valeriana microphylla essential oil AChE BuChE antioxidant activity
Content Type	Text
Resource Type	Article
Subject	Plant Science Ecology Ecology, Evolution, Behavior and Systematics

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