Latest developments on the mechanism of action of membrane disrupting peptides.

Content Provider	Europe PMC
Author	Pandidan, Sara Mechler, Adam
Copyright Year	2021
Abstract	Antimicrobial peptides (AMPs) are integral components of the innate immune defence system of all complex organisms including plants, insects, and mammals. They have wide range of antibacterial, antifungal, antiviral, and even anticancer activities, therefore AMPs are attractive candidates for developing novel therapeutic approaches. Cationic α-helical membrane disrupting peptides are perhaps the most widely studied subclass of AMPs due to their common fundamental characteristics that allow for detailed structure-function analysis and therefore offer a promising solution to the threat of multidrug resistant strains of bacteria. The majority of the studies of AMP activity focused on the biological and biophysical aspects of membrane disruption; the understanding of the molecular mechanism of action from the physicochemical point of view forms a relatively small subfield. This review will provide an overview of these works, focusing on the empirical and thermodynamic models of AMP action.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10244799&blobtype=pdf
ISSN	23643439
Volume Number	7
DOI	10.52601/bpr.2021.200037
PubMed Central reference number	PMC10244799
Issue Number	3
PubMed reference number	37287489
Journal	Biophysics Reports [Biophys Rep]
e-ISSN	23643420
Language	English
Publisher	Biophysics Reports Editorial Office
Publisher Date	2021-06-01
Publisher Place	Beijing China
Access Restriction	Open
Rights License	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Antimicrobial peptides (AMPs) Membrane disrupting peptides Empirical models Thermodynamic models
Content Type	Text
Resource Type	Article
Subject	Biophysics