NDLI: Solid lipid nanoparticles, an effective carrier for classical antifungal drugs.

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Solid lipid nanoparticles, an effective carrier for classical antifungal drugs.

Content Provider	Europe PMC
Author	Almawash, Saud
Copyright Year	2023
Abstract	Solid-lipid nanoparticles (SLNs) are an innovative group of nanosystems used to deliver medicine to their respective targets with better efficiency and bioavailability in contrast to classical formulations. SLNs are less noxious, have fewer adverse effects, have more biocompatibility, and have easy biodegradability. Lipophilic, hydrophilic and hydrophobic drugs can be loaded into SLNs, to enhance their physical and chemical stability in critical environments. Certain antifungal agents used in different treatments are poorly soluble medications, biologicals, proteins etc. incorporated in SLNs to enhance their therapeutic outcome, increase their bioavailability and target specificity. SLNs-based antifungal agents are currently helpful against vicious drug-resistant fungal infections. This review covers the importance of SLNs in drug delivery of classical antifungal drugs, historical background, preparation, physicochemical characteristic, structure and sizes of SLNs, composition, drug entrapment efficacy, clinical evaluations and uses, challenges, antifungal drug resistance, strategies to overcome limitations, novel antifungal agents currently in clinical trials with special emphasis on fungal infections.
ISSN	13190164
Journal	Saudi Pharmaceutical Journal : SPJ
Volume Number	31
PubMed Central reference number	PMC10236373
Issue Number	7
PubMed reference number	37273269
e-ISSN	22137475
DOI	10.1016/j.jsps.2023.05.011
Language	English
Publisher	Elsevier
Publisher Date	2023-05-19
Access Restriction	Open
Rights License	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2023 The Author(s)
Subject Keyword	Solid lipid nanoparticle (SLN) Nanosystems Antifungal drug resistance Drug delivery of classical antifungal medications
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmaceutical Science

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