Loading...
Please wait, while we are loading the content...
Similar Documents
Biological aspects to enhance fracture healing.
| Content Provider | Europe PMC |
|---|---|
| Author | Rodham, Paul L Giannoudis, Vasileios P Kanakaris, Nikolaos K Giannoudis, Peter V |
| Copyright Year | 2023 |
| Abstract | The ability to enhance fracture healing is paramount in modern orthopaedic trauma, particularly in the management of challenging cases including peri-prosthetic fractures, non-union and acute bone loss.Materials utilised in enhancing fracture healing should ideally be osteogenic, osteoinductive, osteoconductive, and facilitate vascular in-growth.Autologous bone graft remains the gold standard, providing all of these qualities. Limitations to this technique include low graft volume and donor site morbidity, with alternative techniques including the use of allograft or xenograft.Artificial scaffolds can provide an osteoconductive construct, however fail to provide an osteoinductive stimulus, and frequently have poor mechanical properties.Recombinant bone morphogenetic proteins can provide an osteoinductive stimulus; however, their licencing is limited and larger studies are required to clarify their role.For recalcitricant non-unions or high-risk cases, the use of composite graft combining the above techniques provides the highest chances of successfully achieving bony union. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10233810&blobtype=pdf |
| Journal | EFORT Open Reviews [EFORT Open Rev] |
| Volume Number | 8 |
| PubMed Central reference number | PMC10233810 |
| Issue Number | 5 |
| PubMed reference number | 37158338 |
| e-ISSN | 20585241 |
| DOI | 10.1530/eor-23-0047 |
| Language | English |
| Publisher | Bioscientifica Ltd |
| Publisher Date | 2023-05-09 |
| Publisher Place | Bristol |
| Access Restriction | Open |
| Rights License | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
| Subject Keyword | bone substitute fracture healing non-union bone graft |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Surgery |
