NDLI: The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery.

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The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery.

Content Provider	Europe PMC
Author	Bian, Juan Gobalasingham, Nemal Purchel, Anatolii Lin, Jessica
Editor	Chandra, Sudeshna Lang, Heinrich
Copyright Year	2023
Abstract	Asymmetric-flow field-flow fractionation (AF4) is a gentle, flexible, and powerful separation technique that is widely utilized for fractionating nanometer-sized analytes, which extend to many emerging nanocarriers for drug delivery, including lipid-, virus-, and polymer-based nanoparticles. To ascertain quality attributes and suitability of these nanostructures as drug delivery systems, including particle size distributions, shape, morphology, composition, and stability, it is imperative that comprehensive analytical tools be used to characterize the native properties of these nanoparticles. The capacity for AF4 to be readily coupled to multiple online detectors (MD-AF4) or non-destructively fractionated and analyzed offline make this technique broadly compatible with a multitude of characterization strategies, which can provide insight on size, mass, shape, dispersity, and many other critical quality attributes. This review will critically investigate MD-AF4 reports for characterizing nanoparticles in drug delivery, especially those reported in the last 10-15 years that characterize multiple attributes simultaneously downstream from fractionation.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28104169
PubMed Central reference number	PMC10224342
Issue Number	10
PubMed reference number	37241911
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-05-18
Access Restriction	Open
Subject Keyword	nanoparticle drug delivery systems asymmetrical flow field-flow fractionation light scattering detection multi-attribute characterization
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry

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