Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies.

Content Provider	Europe PMC
Author	Leite, Fernando Ferreira de Sousa, Natália Ferreira de Oliveira, Bruno Hanrry Melo Duarte, Gabrielly Diniz Ferreira, Maria Denise Leite Scotti, Marcus Tullius Filho, José Maria Barbosa Rodrigues, Luís Cezar de Moura, Ricardo Olímpio Mendonça-Junior, Francisco Jaime Bezerra Scotti, Luciana
Editor	Banskota, Arjun H.
Copyright Year	2023
Abstract	Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability to suppress tumors stands out, in addition to their low toxicity. In this perspective, the present work explores the role of natural and synthetic chalcones and their anticancer activity in vitro reported in the last four years from 2019 to 2023. Moreover, we carried out a partial least square (PLS) analysis of the biologic data reported for colon adenocarcinoma lineage HCT-116. Information was obtained from the Web of Science database. Our in silico analysis identified that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. We hope that the data presented in this work will help researchers to develop effective drugs to inhibit colon adenocarcinoma in future works.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28104009
PubMed Central reference number	PMC10223217
Issue Number	10
PubMed reference number	37241750
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-05-10
Access Restriction	Open
Subject Keyword	chalcones anticancer activity in vitro drug discovery natural products synthesis
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry