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Preparation and Characteristics of Polyethylene Oxide/Curdlan Nanofiber Films by Electrospinning for Biomedical Applications.
| Content Provider | Europe PMC |
|---|---|
| Author | Lin, Shu-Hung Ou, Sin-Liang Hsu, Hung-Ming Wu, Jane-Yii |
| Editor | Espinach Orús, Francisco Javier |
| Copyright Year | 2023 |
| Abstract | In this study, polyethylene oxide (PEO) and curdlan solutions were used to prepare PEO/curdlan nanofiber films by electrospinning using deionized water as the solvent. In the electrospinning process, PEO was used as the base material, and its concentration was fixed at 6.0 wt.%. Moreover, the concentration of curdlan gum varied from 1.0 to 5.0 wt.%. For the electrospinning conditions, various operating voltages (12-24 kV), working distances (12-20 cm) and feeding rates of polymer solution (5-50 μL/min) were also modified. Based on the experimental results, the optimum concentration for the curdlan gum was 2.0 wt.%. Additionally, the most suitable operating voltage, working distance and feeding rate for the electrospinning process were 19 kV, 20 cm and 9 μL/min, respectively, which can help to prepare relatively thinner PEO/curdlan nanofibers with higher mesh porosity and without the formation of beaded nanofibers. Finally, the PEO/curdlan nanofiber instant films containing 5.0 wt.% quercetin inclusion complex were used to perform wetting and disintegration processes. It was found that the instant film can be dissolved significantly on the low-moisture wet wipe. On the other hand, when the instant film touched water, it can be disintegrated very quickly within 5 s, and the quercetin inclusion complex was dissolved in water efficiently. Furthermore, when the instant film encountered the water vapor at 50 °C, it almost completely disintegrated after immersion for 30 min. The results indicate that the electrospun PEO/curdlan nanofiber film is highly feasible for biomedical applications consisting of instant masks and quick-release wound dressings, even in the water vapor environment. |
| Journal | Materials (Basel) |
| Volume Number | 16 |
| DOI | 10.3390/ma16103863 |
| PubMed Central reference number | PMC10220793 |
| Issue Number | 10 |
| PubMed reference number | 37241490 |
| e-ISSN | 19961944 |
| Language | English |
| Publisher | Molecular Diversity Preservation International (MDPI) |
| Publisher Date | 2023-05-20 |
| Access Restriction | Open |
| Subject Keyword | electrospinning polyethylene oxide curdlan nanofiber films wetting time disintegration time |
| Content Type | Text |
| Resource Type | Article |
| Subject | Condensed Matter Physics Materials Science |
