Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial.

Content Provider	Europe PMC
Author	Cavero-Redondo, Iván Saz-Lara, Alicia Martínez-García, Irene Bizzozero-Peroni, Bruno Díaz-Goñi, Valentina Díez-Fernández, Ana Moreno-Herráiz, Nerea Pascual-Morena, Carlos
Editor	Andrès, Emmanuel
Copyright Year	2023
Abstract	(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF.
Journal	Journal of Clinical Medicine [J Clin Med]
Volume Number	12
DOI	10.3390/jcm12103535
PubMed Central reference number	PMC10218785
Issue Number	10
PubMed reference number	37240641
e-ISSN	20770383
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-05-18
Access Restriction	Open
Subject Keyword	physical exercise heart failure exercise capacity diastolic function endothelial function arterial stiffness
Content Type	Text
Resource Type	Article
Subject	Medicine