NDLI: Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins.

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Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins.

Content Provider	Europe PMC
Author	Radford, Holly M. Toft, Casey J. Sorenson, Alanna E. Schaeffer, Patrick M.
Editor	Wegrzyn, Grzegorz Bianco, Piero R.
Copyright Year	2023
Abstract	Over 1.2 million deaths are attributed to multi-drug-resistant (MDR) bacteria each year. Persistence of MDR bacteria is primarily due to the molecular mechanisms that permit fast replication and rapid evolution. As many pathogens continue to build resistance genes, current antibiotic treatments are being rendered useless and the pool of reliable treatments for many MDR-associated diseases is thus shrinking at an alarming rate. In the development of novel antibiotics, DNA replication is still a largely underexplored target. This review summarises critical literature and synthesises our current understanding of DNA replication initiation in bacteria with a particular focus on the utility and applicability of essential initiation proteins as emerging drug targets. A critical evaluation of the specific methods available to examine and screen the most promising replication initiation proteins is provided.
Journal	International Journal of Molecular Sciences [Int J Mol Sci]
Volume Number	24
DOI	10.3390/ijms24108802
PubMed Central reference number	PMC10218098
Issue Number	10
PubMed reference number	37240152
e-ISSN	14220067
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-05-15
Access Restriction	Open
Subject Keyword	DNA replication antibiotics primase helicase high-throughput screening replication fork replisome DnaA bacteria
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry

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