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Diabetic Nephropathy and Gaseous Modulators.
| Content Provider | Europe PMC |
|---|---|
| Author | Juin, Subir Kumar Ouseph, Rosemary Gondim, Dibson Dibe Jala, Venkatakrishna Rao Sen, Utpal |
| Editor | Kim, Cuk-Seong |
| Copyright Year | 2023 |
| Abstract | Diabetic nephropathy (DN) remains the leading cause of vascular morbidity and mortality in diabetes patients. Despite the progress in understanding the diabetic disease process and advanced management of nephropathy, a number of patients still progress to end-stage renal disease (ESRD). The underlying mechanism still needs to be clarified. Gaseous signaling molecules, so-called gasotransmitters, such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), have been shown to play an essential role in the development, progression, and ramification of DN depending on their availability and physiological actions. Although the studies on gasotransmitter regulations of DN are still emerging, the evidence revealed an aberrant level of gasotransmitters in patients with diabetes. In studies, different gasotransmitter donors have been implicated in ameliorating diabetic renal dysfunction. In this perspective, we summarized an overview of the recent advances in the physiological relevance of the gaseous molecules and their multifaceted interaction with other potential factors, such as extracellular matrix (ECM), in the severity modulation of DN. Moreover, the perspective of the present review highlights the possible therapeutic interventions of gasotransmitters in ameliorating this dreaded disease. |
| Journal | Antioxidants (Basel, Switzerland) |
| Volume Number | 12 |
| PubMed Central reference number | PMC10215699 |
| Issue Number | 5 |
| PubMed reference number | 37237955 |
| e-ISSN | 20763921 |
| DOI | 10.3390/antiox12051088 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-05-12 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | diabetic nephropathy nitric oxide carbon monoxide hydrogen sulfide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Cell Biology Molecular Biology Physiology Clinical Biochemistry Food Science |
