NDLI: Peptide Regulation of Chondrogenic Stem Cell Differentiation.

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Peptide Regulation of Chondrogenic Stem Cell Differentiation.

Content Provider	Europe PMC
Author	Linkova, Natalia Khavinson, Vladimir Diatlova, Anastasiia Myakisheva, Svetlana Ryzhak, Galina
Editor	Melino, Sonia
Copyright Year	2023
Abstract	The search for innovative ways to treat osteoarthritis (OA) is an urgent task for molecular medicine and biogerontology. OA leads to disability in persons of middle and older age, while safe and effective methods of treating OA have not yet been discovered. The directed differentiation of mesenchymal stem cells (MSCs) into chondrocytes is considered one of the possible methods to treat OA. This review describes the main molecules involved in the chondrogenic differentiation of MSCs. The peptides synthesized on the basis of growth factors' structures (SK2.1, BMP, B2A, and SSPEPS) and components of the extracellular matrix of cartilage tissue (LPP, CFOGER, CMP, RDG, and N-cadherin mimetic peptide) offer the greatest promise for the regulation of the chondrogenic differentiation of MSCs. These peptides regulate the WNT, ERK-p38, and Smad 1/5/8 signaling pathways, gene expression, and the synthesis of chondrogenic differentiation proteins such as COL2, SOX9, ACAN, etc.
Journal	International Journal of Molecular Sciences [Int J Mol Sci]
Volume Number	24
DOI	10.3390/ijms24098415
PubMed Central reference number	PMC10179481
Issue Number	9
PubMed reference number	37176122
e-ISSN	14220067
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-05-08
Access Restriction	Open
Subject Keyword	osteoarthritis mesenchymal stem cells chondrogenic differentiation peptides growth factors
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry

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