The prevalence of abnormal right ventricle speckle strain in the setting of acute myocarditis and preserved left ventricle function.

Content Provider	Europe PMC
Author	Ben-Joya, Daniel Kaplan, Alon Baruch, Guy Rothschild, Ehud Beer, Gil Banai, Shmuel Topilsky, Yan Kapusta, Livia Laufer-Perl, Michal
Abstract	BackgroundAcute myocarditis has a wide spectrum of clinical presentation, from subclinical disease to acute heart failure, and sudden cardiac death. Two-dimensional speckle tracking echocardiography (2D-STE) has been proven effective in early diagnosis of subclinical cardiac injury, however, there is a limited data regarding the right ventricle (RV) involvement among patients with acute myocarditis.PurposeWe evaluated the prevalence of early subclinical RV injury assessed by 2D-STE, among patients with acute myocarditis and preserved left ventricle (LV) function.MethodsWe performed a retrospective single-center study at Tel-Aviv Sourasky Medical Center, including all adult patients hospitalized with acute myocarditis, who presented with preserved LV function. 2D-STE analysis of the RV was performed offline, assessing both the RV four-chamber longitudinal strain peak systolic (RV4CLS PK) and the free wall longitudinal strain peak systolic (RVFWLS PK). The myocarditis group was compared to a healthy control group.ResultsFrom 2011 to 2020, a total of 90 patients included in the study and were compared to 70 healthy subjects. RV 2D-STE emerged as significantly lower for both the RV4CLS PK (-21.8 ± 4.2 vs. -24.9 ± 4.8, P < 0.001) and RVFWLS PK (-24.7 ± 4.9 vs. -28.4 ± 5, P < 0.001), and remained significant in a multivariate analysis.ConclusionWe presented for the first time the presence of subclinical RV dysfunction, assessed by 2D-STE, in patients diagnosed with acute myocarditis, in the presence of preserved LV function. Further studies are needed to evaluate its’ role in the development of LV dysfunction, heart failure and mortality.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10554-023-02829-7.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10163986&blobtype=pdf
ISSN	15695794
Journal	The International Journal of Cardiovascular Imaging [Int J Cardiovasc Imaging]
Volume Number	39
DOI	10.1007/s10554-023-02829-7
PubMed Central reference number	PMC10163986
Issue Number	7
PubMed reference number	37149840
e-ISSN	18758312
Language	English
Publisher	Springer Netherlands
Publisher Date	2023-05-07
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Subject Keyword	Myocarditis Echocardiography Strain Right ventricle RV4CLS RVFWLS
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine