Hepatic artery and portal vein Doppler ultrasound reference values in children aged 0-17 years old.

Content Provider	Europe PMC
Author	Verhagen, Martijn V Kwee, Thomas C de Haas, Robbert J
Copyright Year	2022
Description	Introduction: Doppler ultrasound of the portal vein peak systolic velocity and hepatic artery peak systolic velocity and resistive index in children is often performed during abdominal ultrasound for the assessment of liver and other abdominal pathology. However, evidence-based reference values are not available. We aimed to determine these reference values and to investigate whether they are age-dependent. Methods: Children who underwent abdominal ultrasound between 2020 and 2021 were retrospectively identified. Patients without hepatic or cardiac abnormalities at the time of ultrasound or during at least 3 months follow-up were eligible for the study. Ultrasound without hepatic hilum portal vein peak systolic velocity and/or hepatic artery peak systolic velocity and resistive index measurements were excluded. Age-dependent changes were analyzed using linear regression. Normal range reference values were described using percentiles for all ages, and for age subgroups. Results: One-hundred ultrasound examinations performed in 100 healthy children aged 0–17.9 years (median 7.8 years, interquartile range 1.1–14.1 years) were included. Ninety-nine portal vein peak systolic velocity and 80 hepatic artery peak systolic velocity and resistive index measurements were obtained. There was no significant association between portal vein peak systolic velocity and age (β = −0.056, p = 0.68). There were significant associations between age and hepatic artery peak systolic velocity, and between age and hepatic artery resistive index (β = −0.873, p = 0.04 and β = −0.004, p < 0.001, respectively). Detailed reference values were provided for all ages, and for age subgroups. Conclusion: Reference values for the hepatic hilum portal vein peak systolic velocity, hepatic artery peak systolic velocity, and hepatic artery resistive index in children were established. Portal vein peak systolic velocity is not age-dependent, whereas hepatic artery peak systolic velocity and hepatic artery resistive index decrease when children get older.
Abstract	Introduction: Doppler ultrasound of the portal vein peak systolic velocity and hepaticartery peak systolic velocity and resistive index in children is oftenperformed during abdominal ultrasound for the assessment of liver and otherabdominal pathology. However, evidence-based reference values are notavailable. We aimed to determine these reference values and to investigatewhether they are age-dependent. Methods: Children who underwent abdominal ultrasound between 2020 and 2021 wereretrospectively identified. Patients without hepatic or cardiacabnormalities at the time of ultrasound or during at least 3 monthsfollow-up were eligible for the study. Ultrasound without hepatic hilumportal vein peak systolic velocity and/or hepatic artery peak systolicvelocity and resistive index measurements were excluded. Age-dependentchanges were analyzed using linear regression. Normal range reference valueswere described using percentiles for all ages, and for age subgroups. Results: One-hundred ultrasound examinations performed in 100 healthy children aged0–17.9 years (median 7.8 years, interquartile range 1.1–14.1 years) wereincluded. Ninety-nine portal vein peak systolic velocity and 80 hepaticartery peak systolic velocity and resistive index measurements wereobtained. There was no significant association between portal vein peaksystolic velocity and age (β = −0.056, p = 0.68). Therewere significant associations between age and hepatic artery peak systolicvelocity, and between age and hepatic artery resistive index (β = −0.873,p = 0.04 and β = −0.004, p < 0.001,respectively). Detailed reference values were provided for all ages, and forage subgroups. Conclusion: Reference values for the hepatic hilum portal vein peak systolic velocity,hepatic artery peak systolic velocity, and hepatic artery resistive index inchildren were established. Portal vein peak systolic velocity is notage-dependent, whereas hepatic artery peak systolic velocity and hepaticartery resistive index decrease when children get older.
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ISSN	1742271X
Volume Number	31
PubMed Central reference number	PMC10152319
Issue Number	2
PubMed reference number	37144228
Journal	Ultrasound: Journal of the British Medical Ultrasound Society [Ultrasound]
e-ISSN	17431344
DOI	10.1177/1742271x221114050
Language	English
Publisher	SAGE Publications
Publisher Date	2022-08-08
Publisher Place	Sage UK: London, England
Access Restriction	Open
Rights License	© The Author(s) 2022
Subject Keyword	Reference values hepatic artery portal vein pediatric sonography medical
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology