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The emergence of multi-drug-resistant bacteria causing healthcare-associated infections in COVID-19 patients: a retrospective multi-centre study.
| Content Provider | Europe PMC |
|---|---|
| Author | Gajic, I. Jovicevic, M. Popadic, V. Trudic, A. Kabic, J. Kekic, D. Ilic, A. Klasnja, S. Hadnadjev, M. Popadic, D.J. Andrijevic, A. Prokic, A. Tomasevic, R. Ranin, L. Todorovic, Z. Zdravkovic, M. Opavski, N. |
| Copyright Year | 2023 |
| Abstract | IntroductionWe evaluated the prevalence, aetiologies and antibiotic resistance patterns of bacterial infections in hospitalized patients with laboratory-confirmed SARS-CoV-2. We also investigated comorbidities, risk factors and the mortality rate in COVID-19 patients with bacterial infections.MethodsThis retrospective observational study evaluated medical records of 7249 randomly selected patients with COVID-19 admitted to three clinical centres between 1st January 2021 and 16th February 2022. A total of 6478 COVID-19 patients met the eligibility criteria for analysis.ResultsThe mean age of the patients with SARS-CoV-2 and bacterial infections was 68.6 ± 15.5 years (range: 24–94 years). The majority of patients (68.7%) were older than 65 years. The prevalence of bacterial infections among hospitalized COVID-19 patients was 12.9%, most of them being hospital-acquired (11.5%). Bloodstream (37.7%) and respiratory tract infections (25.6%) were the most common bacterial infections. Klebsiella pneumoniae and Acinetobacter baumannii caused 25.2% and 23.6% of all bacterial infections, respectively. Carbapenem-resistance in Enterobacterales, A. baumannii and Pseudomonas aeruginosa were 71.3%, 93.8% and 69.1%, respectively. Age >60 years and infections caused by ≥3 pathogens were significantly more prevalent among deceased patients compared with survivors (P<0.05). Furthermore, 95% of patients who were intubated developed ventilator-associated pneumonia. The overall in-hospital mortality rate of patients with SARS-CoV-2 and bacterial infections was 51.6%, while 91.7% of patients who required invasive mechanical ventilation died.ConclusionsOur results reveal a striking association between healthcare-associated bacterial infections as an important complication of COVID-19 and fatal outcomes. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10140260&blobtype=pdf |
| ISSN | 01956701 |
| Journal | The Journal of Hospital Infection [J Hosp Infect] |
| Volume Number | 137 |
| DOI | 10.1016/j.jhin.2023.04.013 |
| PubMed Central reference number | PMC10140260 |
| PubMed reference number | 37121488 |
| e-ISSN | 15322939 |
| Language | English |
| Publisher | The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. |
| Publisher Date | 2023-04-28 |
| Access Restriction | Open |
| Rights License | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. © 2023 The Authors |
| Subject Keyword | Bacterial infections Antimicrobial resistance SARS-CoV-2 COVID-19 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology (medical) |
