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Optimization of Mixed Inulin, Fructooligosaccharides, and Galactooligosaccharides as Prebiotics for Stimulation of Probiotics Growth and Function.
| Content Provider | Europe PMC |
|---|---|
| Author | Kaewarsar, Ekkachai Chaiyasut, Chaiyavat Lailerd, Narissara Makhamrueang, Netnapa Peerajan, Sartjin Sirilun, Sasithorn |
| Editor | Yu, Leilei |
| Copyright Year | 2023 |
| Abstract | Prebiotics have become an important functional food because of their potential for modulating the gut microbiota and metabolic activities. However, different prebiotics can stimulate the growth of different probiotics. The optimization of prebiotics was focused on in this study in order to stimulate the representative probiotics’ growth (Lacticaseibacillus rhamnosus (previously Lactobacillus rhamnosus) and Bifidobacterium animalis subsp. lactis) and their function. The culture medium was supplemented with three prebiotics, including inulin (INU), fructooligosaccharides (FOS), and galactooligosaccharides (GOS). All prebiotics can clearly stimulate the growth of probiotic strains in both monoculture and co-culture. The specific growth rates of L. rhamnosus and B. animalis subsp. lactis were shown in GOS (0.019 h−1) and FOS (0.023 h−1), respectively. The prebiotic index (PI) scores of INU (1.03), FOS (0.86), and GOS (0.84) in co-culture at 48 h were significantly higher than the control (glucose). The mixture of prebiotics to achieve high quality was optimized using the Box–Behnken design. The optimum prebiotic ratios of INU, FOS, and GOS were 1.33, 2.00, and 2.67% w/v, respectively, with the highest stimulated growth of probiotic strains occurring with the highest PI score (1.03) and total short chain fatty acid concentration (85.55 µmol/mL). The suitable ratio of mixed prebiotics will function as a potential ingredient for functional foods or colonic foods. |
| Journal | Foods (Basel, Switzerland) |
| Volume Number | 12 |
| PubMed Central reference number | PMC10137966 |
| Issue Number | 8 |
| PubMed reference number | 37107386 |
| e-ISSN | 23048158 |
| DOI | 10.3390/foods12081591 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-04-09 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | colonic food gut microbiota oligosaccharides prebiotics probiotics synbiotics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology Health (social science) Health Professions Food Science Plant Science |
