NDLI: The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma.

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The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma.

Content Provider	Europe PMC
Author	Wei, Yuanyuan Khalaf, Ahmad Taha Rui, Cao Abdul Kadir, Samiah Yasmin Zainol, Jamaludin Oglah, Zahraa
Editor	Niikura, Ryota
Copyright Year	2023
Abstract	Integral membrane proteins, known as Transient Receptor Potential (TRP) channels, are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.
Journal	Biomedicines
Volume Number	11
PubMed Central reference number	PMC10136338
Issue Number	4
PubMed reference number	37189782
e-ISSN	22279059
DOI	10.3390/biomedicines11041164
Language	English
Publisher	MDPI
Publisher Date	2023-04-13
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	pancreatic cancer ductal carcinoma adenocarcinoma tumor TRP channel pathogenesis
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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