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Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons.
| Content Provider | Europe PMC |
|---|---|
| Author | Aparicio, Gabriela I. León, Antonella Gutiérrez Fuster, Rocío Ravenscraft, Baylen Monje, Paula V. Scorticati, Camila |
| Editor | Yip, Ping K. |
| Copyright Year | 2023 |
| Abstract | The peripheral nervous system (PNS) has a unique ability for self-repair. Dorsal root ganglion (DRG) neurons regulate the expression of different molecules, such as neurotrophins and their receptors, to promote axon regeneration after injury. However, the molecular players driving axonal regrowth need to be better defined. The membrane glycoprotein GPM6a has been described to contribute to neuronal development and structural plasticity in central-nervous-system neurons. Recent evidence indicates that GPM6a interacts with molecules from the PNS, although its role in DRG neurons remains unknown. Here, we characterized the expression of GPM6a in embryonic and adult DRGs by combining analysis of public RNA-seq datasets with immunochemical approaches utilizing cultures of rat DRG explants and dissociated neuronal cells. M6a was detected on the cell surfaces of DRG neurons throughout development. Moreover, GPM6a was required for DRG neurite elongation in vitro. In summary, we provide evidence on GPM6a being present in DRG neurons for the first time. Data from our functional experiments support the idea that GPM6a could contribute to axon regeneration in the PNS. |
| Journal | Biomolecules |
| Volume Number | 13 |
| PubMed Central reference number | PMC10136334 |
| Issue Number | 4 |
| PubMed reference number | 37189342 |
| e-ISSN | 2218273X |
| DOI | 10.3390/biom13040594 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-03-25 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | GPM6A glycoprotein dorsal root ganglion neurons peripheral nervous system neuritogenesis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Molecular Biology |
