NDLI: Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake.

Please wait, while we are loading the content...

Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake.

Content Provider	Europe PMC
Author	Coelho, Filipe Saidjalolov, Saidbakhrom Moreau, Dimitri Thorn-Seshold, Oliver Matile, Stefan
Copyright Year	2023
Abstract	Integrins are cellsurface proteins responsible for cell motility.Inspired by the rich disulfide exchange chemistry of integrins, weshow here the inhibition of cell migration by cascade exchangers (CAXs),which also enable and inhibit cell penetration by thiol-mediated uptake.Fast-moving CAXs such as reversible Michael acceptor dimers, dithiabismepanes,and bioinspired epidithiodiketopiperazines are best, much better thanEllman’s reagent. The implication that integrins participatein thiol-mediated uptake is confirmed by reduced uptake in integrin-knockdowncells. Although thiol-mediated uptake is increasingly emerging asa unifying pathway to bring matter into cells, its molecular basisis essentially unknown. These results identify the integrin superfamilyas experimentally validated general cellular partners in the dynamiccovalent exchange cascades that are likely to account for thiol-mediateduptake. The patterns identified testify to the complexity of the dynamic covalent networks involved. This work also provides chemistrytools to explore cell motility and expands the drug discovery potentialof CAXs from antiviral toward antithrombotic and antitumor perspectives.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10131202&blobtype=pdf
Journal	JACS Au
Volume Number	3
DOI	10.1021/jacsau.3c00113
PubMed Central reference number	PMC10131202
Issue Number	4
PubMed reference number	37124287
e-ISSN	26913704
Language	English
Publisher	American Chemical Society
Publisher Date	2023-04-12
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2023 The Authors. Published by American Chemical Society
Subject Keyword	cell motility thiol-mediated uptake integrins inhibitors dynamic covalent inhibitors
Content Type	Text
Resource Type	Article
Subject	Chemistry Physical and Theoretical Chemistry Analytical Chemistry Organic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in