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Comparison of Particulate, Block and Putty Forms of β-tricalcium Phosphate-Based Synthetic Bone Grafts on Rat Calvarium Model.
| Content Provider | Europe PMC |
|---|---|
| Author | Akçay, Hüseyin Tatar, Birkan Kuru, Keremcan Ünal, Nuri Şimşek, Fatma Ulu, Murat Karaman, Ozan |
| Abstract | Purpose Bone augmentation is a necessity for atrophied alveolar ridge prior to dental implant placement. Various bone graft types and forms with different characteristics are available in the market for alveolar augmentation. Beta tricalcium phosphate (β-TCP) is a synthetic biomaterial known as the oldest type of calcium phosphate. Studies comparing particulate, block or putty grafts are very limited. The aim of this study was to compare the particulate, block and putty forms of the same β-TCP bone graft and analyze the efficiency in critical size calvarium defects. Material and Methods Twenty male Wistar-Albino rats were employed for the study. Four bicortical bone defects with 5 mm diameter were created on each rat calvarium, and three defects were filled with particulate, block or putty β-TCP graft and one defect was left empty. The animals were killed after 8 weeks. New bone formation, residual graft, loose connective tissue, condensed mesenchyme, alkaline phosphatase, proliferating cell nuclear antigen, osteocalcin were measured on the specimens. Results Compared to block and putty forms, significantly higher new bone formation and least residual graft were observed in the particulate graft group. The residual graft was significantly higher in the block graft group than both the particulate and the putty groups. The cellular immunoreactivity of the samples in the particulate graft group was significantly higher. There was no significant difference between putty and block graft groups. Conclusion Bone regeneration is significantly affected by the form of β-TCP bone graft, and the particulate form was the most successful in our study. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10130241&blobtype=pdf |
| ISSN | 09728279 |
| Volume Number | 22 |
| DOI | 10.1007/s12663-022-01735-0 |
| PubMed Central reference number | PMC10130241 |
| Issue Number | 2 |
| PubMed reference number | 37122788 |
| Journal | Journal of Maxillofacial & Oral Surgery [J Maxillofac Oral Surg] |
| e-ISSN | 0974942X |
| Language | English |
| Publisher | Springer India |
| Publisher Date | 2022-05-27 |
| Publisher Place | New Delhi |
| Access Restriction | Open |
| Rights License | © The Association of Oral and Maxillofacial Surgeons of India 2022 |
| Subject Keyword | Beta-tricalcium phosphate Alveolar bone grafting Dental implants Alveolar ridge augmentation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Oral Surgery Surgery |
