Regulated cell death in cancer: from pathogenesis to treatment.

Content Provider	Europe PMC
Author	Gong, Linjing Huang, Dong Shi, Yujun Liang, Zong’an Bu, Hong
Editor	Ni, Jing
Copyright Year	2022
Abstract	AbstractRegulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is regulated by a series of evolutionarily conserved pathways, and is required for development and tissue homeostasis. Based on previous genetic and biochemical explorations of cell death subroutines, the characteristics of each are generally considered distinctive. However, recent in-depth studies noted the presence of crosstalk between the different forms of RCD; hence, the concept of PANoptosis appeared. Cancer, a complex genetic disease, is characterized by stepwise deregulation of cell apoptosis and proliferation, with significant morbidity and mortality globally. At present, studies on the different RCD pathways, as well as the intricate relationships between different cell death subroutines, mainly focus on infectious diseases, and their roles in cancer remain unclear. As cancers are characterized by dysregulated cell death and inflammatory responses, most current treatment strategies aim to selectively induce cell death via different RCD pathways in cancer cells. In this review, we describe five types of RCD pathways in detail with respect to tumorigenesis and cancer progression. The potential value of some of these key effector molecules in tumor diagnosis and therapeutic response has also been raised. We then review and highlight recent progress in cancer treatment based on PANoptosis and ferroptosis induced by small-molecule compounds, immune checkpoint inhibitors, and nanoparticles. Together, these findings may provide meaningful evidence to fill in the gaps between cancer pathogenesis and RCD pathways to develop better cancer therapeutic strategies.
ISSN	03666999
Volume Number	136
PubMed Central reference number	PMC10129203
Issue Number	6
PubMed reference number	35950752
Journal	Chinese Medical Journal [Chin Med J (Engl)]
e-ISSN	25425641
DOI	10.1097/CM9.0000000000002239
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2023-03-20
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.
Subject Keyword	Anti-cancer therapy Apoptosis Cancer Programmed cell death Pyroptosis PANoptosis Necroptosis Ferroptosis Diagnosis
Content Type	Text
Resource Type	Article
Subject	Medicine