Carbene Radicals in Transition-Metal-Catalyzed Reactions.

Content Provider	Europe PMC
Author	Epping, Roel F.J. Vesseur, David Zhou, Minghui de Bruin, Bas
Copyright Year	2023
Abstract	Discovered as organometallic curiosities in the 1970s,carbeneradicals have become a staple in modern-day homogeneous catalysis.Carbene radicals exhibit nucleophilic radical-type reactivity orthogonalto classical electrophilic diamagnetic Fischer carbenes. Their successfulcatalytic application has led to the synthesis of a myriad of carbo-and heterocycles, ranging from simple cyclopropanes to more challengingeight-membered rings. The field has matured to employ densely functionalizedchiral porphyrin-based platforms that exhibit high enantio-, regio-,and stereoselectivity. Thus far the focus has largely been on cobalt-basedsystems, but interest has been growing for the past few years to expandthe application of carbene radicals to other transition metals. ThisPerspective covers the advances made since 2011 and gives an overviewon the coordination chemistry, reactivity, and catalytic applicationof carbene radical species using transition metal complexes and catalysts.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10127290&blobtype=pdf
Journal	ACS Catalysis [ACS Catal]
Volume Number	13
DOI	10.1021/acscatal.3c00591
PubMed Central reference number	PMC10127290
Issue Number	8
PubMed reference number	37123600
e-ISSN	21555435
Language	English
Publisher	American Chemical Society
Publisher Date	2023-04-06
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2023 The Authors. Published by American Chemical Society
Subject Keyword	carbene radical metallocarbene transitionmetal catalysis radical chemistry metalloradicalcatalysis cobalt catalysis
Content Type	Text
Resource Type	Article
Subject	Chemistry Catalysis