NDLI: Aneuploidy Is Associated with Azole Resistance in Aspergillus fumigatus.

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Aneuploidy Is Associated with Azole Resistance in Aspergillus fumigatus.

Content Provider	Europe PMC
Author	Khateb, Aiah Gago, Sara Bromley, Michael Richardson, Malcom Bowyer, Paul
Copyright Year	2023
Abstract	Azole resistance in Aspergillus fumigatus is on the rise. Nontarget-mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA). Here, we investigate resistance mechanisms using whole-genome sequencing. Sixteen azole-resistant A. fumigatus isolates from CPA were sequenced to assess genome rearrangements. Seven out of 16 CPA isolates showed genomic duplications compared to zero out of 18 invasive isolates. Duplication of regions, including cyp51A, increased gene expression. Our results suggest aneuploidy as an azole resistance mechanism in CPA.
Page Count	5
ISSN	00664804
Journal	Antimicrobial Agents and Chemotherapy
Volume Number	67
PubMed Central reference number	PMC10112202
Issue Number	4
PubMed reference number	36975834
e-ISSN	10986596
DOI	10.1128/aac.01253-22
Language	English
Publisher	American Society for Microbiology
Publisher Date	2023-03-28
Publisher Place	N.W., Washington, DC
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. Copyright © 2023 Khateb et al.
Subject Keyword	Aspergillus fumigatus Mycology antifungal resistance azole genome analysis genome organization
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology Pharmacology (medical)

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