NDLI: Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection.

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Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection.

Content Provider	Europe PMC
Author	Wu, Chao Guo, Lianghua Muhataer, Xirennayi Li, Qifeng Lian, Zhichuang Li, Yafang Wang, Wenyi Ding, Wei Zhou, Yuan Yang, Xiaohong Chen, Muzhi
Copyright Year	2023
Abstract	AbstractThis study examined the effects of the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count after pulmonary infection. Sprague‒Dawley rats were subjected to tracheal injection of lipopolysaccharide (LPS) to establish animal models of pulmonary infection. By inhibiting the PI3K/AKT pathway or inhibiting/inducing mitochondrial autophagy in macrophages, the severity of the pulmonary infection and the leukocyte count were altered. The PI3K/AKT inhibition group did not show a significant difference in leukocyte counts compared with the infection model group. Mitochondrial autophagy induction alleviated the pulmonary inflammatory response. The infection model group had significantly higher levels of LC3B, Beclin1, and p-mTOR than the control group. The AKT2 inhibitor group exhibited significantly increased levels of LC3B and Beclin1 compared with the control group (P < 0.05), and the Beclin1 level was significantly higher than that in the infection model group (P < 0.05). Compared with the infection model group, the mitochondrial autophagy inhibitor group exhibited significantly decreased levels of p-AKT2 and p-mTOR, whereas the levels of these proteins were significantly increased in the mitochondrial autophagy inducer group (P < 0.05). PI3K/AKT inhibition promoted mitochondrial autophagy in macrophages. Mitochondrial autophagy induction activated the downstream gene mTOR of the PI3K/AKT pathway, alleviated pulmonary inflammatory reactions, and decreased leukocyte counts.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10106970&blobtype=pdf
Page Count	10
Journal	Open Life Sciences [Open Life Sci]
Volume Number	18
DOI	10.1515/biol-2022-0588
PubMed Central reference number	PMC10106970
Issue Number	1
PubMed reference number	37077346
e-ISSN	23915412
Language	English
Publisher	De Gruyter
Publisher Date	2023-04-15
Access Restriction	Open
Rights License	This work is licensed under the Creative Commons Attribution 4.0 International License. © 2023 the author(s), published by De Gruyter
Subject Keyword	severe pneumonia leukocyte mitochondrial autophagy PI3K-AKT-mTOR pathway molecule
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Neuroscience Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology

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