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Survival outcomes after synchronous para-aortic lymph node metastasis in colorectal cancer: A systematic review.
| Content Provider | Europe PMC |
|---|---|
| Author | Aylward, Conor Noori, Jawed Tyrrell, Jack O'sullivan, Niall Kavanagh, Dara O. Larkin, John O. Mehigan, Brian J. McCormick, Paul H. Kelly, Michael E. |
| Abstract | AbstractBackgroundSynchronous para‐aortic lymph node metastasis (PALNM) in colorectal cancer (CRC) is a relatively rare clinical entity. There is a lack of consensus on management of these patients, and the role of para‐aortic lymph node dissection (PALND) remains controversial. This systematic review aims to describe the survival outcomes in colorectal cancer with synchronous PALNM when lymph node dissection is performed.MethodsA systematic review of Pubmed, Embase and Web of Science databases for PALND in CRC was performed. Studies including patients with synchronous PALNM undergoing resection with curative intent, published from the year 2000 onwards, were included.ResultsTwelve retrospective studies were included. Four studies reported survival outcomes for rectal cancer, two for colon cancer and six as colorectal. Survival outcomes for 356 patients were included. Average 5‐year overall survival (OS) was 22.4%, 33.9% and 37.7% in the rectal, colon and colorectal groups respectively. Three year OS in the groups was 53.6%, 46.2% and 65.7%.ConclusionThere remains a lack of quality data to confidently make recommendations regarding the management of synchronous PALNM in colon and rectal cancer cohorts. Retrospective data suggests a benefit in highly selective cohorts and therefore a case‐by‐case evaluation remains the standard of care. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10100040&blobtype=pdf |
| Page Count | 12 |
| ISSN | 00224790 |
| Journal | Journal of Surgical Oncology [J Surg Oncol] |
| Volume Number | 127 |
| DOI | 10.1002/jso.27139 |
| PubMed Central reference number | PMC10100040 |
| Issue Number | 4 |
| PubMed reference number | 36350234 |
| e-ISSN | 10969098 |
| Language | English |
| Publisher | John Wiley and Sons Inc. |
| Publisher Date | 2022-11-09 |
| Publisher Place | Hoboken |
| Access Restriction | Open |
| Rights License | This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. |
| Subject Keyword | dissection lower GI metastatic neoplasm rectal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery Oncology |
