Palladium-Catalyzed Stereoselective Construction of 1,3-Stereocenters Displaying Axial and Central Chirality via Asymmetric Alkylations.

Content Provider	Europe PMC
Author	Xue, Aiqi Wei, Xingfu Huang, Yue Qu, Jingping Wang, Baomin
Editor	Benaglia, Maurizio
Copyright Year	2023
Abstract	The concurrent construction of 1,3-stereocenters remains a challenge. Herein, we report the development of stereoselective union of a point chiral center with allenyl axial chirality in 1,3-position by Pd-catalyzed asymmetric allenylic alkylation between racemic allenyl carbonates and indanone-derived β-ketoesters. Various target products bearing a broad range of functional groups were afforded in high yield (up to 99%) with excellent enantioselectivities (up to 98% ee) and good diastereoselectivities (up to 13:1 dr).
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28072927
PubMed Central reference number	PMC10096308
Issue Number	7
PubMed reference number	37049689
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-03-24
Access Restriction	Open
Subject Keyword	Pd-catalysis 1,3-stereocenters axial and central chirality asymmetric alkylation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry