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Fructose drives de novo lipogenesis affecting metabolic health.
| Content Provider | Europe PMC |
|---|---|
| Author | Geidl-Flueck, Bettina Gerber, Philipp A |
| Copyright Year | 2023 |
| Abstract | Despite the existence of numerous studies supporting a pathological link between fructose consumption and the development of the metabolic syndrome and its sequelae, such as non-alcoholic fatty liver disease (NAFLD), this link remains a contentious issue. With this article, we shed a light on the impact of sugar/fructose intake on hepatic de novo lipogenesis (DNL), an outcome parameter known to be dysregulated in subjects with type 2 diabetes and/or NAFLD. In this review, we present findings from human intervention studies using physiological doses of sugar as well as mechanistic animal studies. There is evidence from both human and animal studies that fructose is a more potent inducer of hepatic lipogenesis than glucose. This is most likely due to the liver’s prominent physiological role in fructose metabolism, which may be disrupted under pathological conditions by increased hepatic expression of fructolytic and lipogenic enzymes. Increased DNL may not only contribute to ectopic fat deposition (i.e. in the liver), but it may also impair several metabolic processes through DNL-related fatty acids (e.g. beta-cell function, insulin secretion, or insulin sensitivity). |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10083579&blobtype=pdf |
| ISSN | 00220795 |
| Journal | The Journal of Endocrinology [J Endocrinol] |
| Volume Number | 257 |
| PubMed Central reference number | PMC10083579 |
| Issue Number | 2 |
| PubMed reference number | 36753292 |
| e-ISSN | 14796805 |
| DOI | 10.1530/joe-22-0270 |
| Language | English |
| Publisher | Bioscientifica Ltd |
| Publisher Date | 2023-03-27 |
| Publisher Place | Bristol |
| Access Restriction | Open |
| Rights License | This work is licensed under a Creative Commons Attribution 4.0 International License. © The authors |
| Subject Keyword | sugar glucose fructose de novo lipogenesis fatty acids |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
