Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances.

Content Provider	Europe PMC
Author	Ostash, Bohdan Makitrynskyy, Roman Yushchuk, Oleksandr Fedorenko, Victor
Copyright Year	2022
Abstract	Moenomycins, such as moenomycin A, are phosphoglycolipid specialized metabolites produced by a number of actinobacterial species. They are among the most potent antibacterial compounds known to date, which drew numerous studies directed at various aspects of the chemistry and biology of moenomycins. In this review, we outline the advances in moenomycin research over the last decade. We focus on biological aspects, highlighting the contribution of the novel methods of genomics and molecular biology to the deciphering of the biosynthesis and activity of moenomycins. Specifically, we describe the structural diversity of moenomycins as well as the underlying genomic variations in moenomycin biosynthetic gene clusters. We also describe the most recent data on the mechanism of action and assembly of complicated phosphoglycolipid scaffold. We conclude with the description of the genetic control of moenomycin production by Streptomyces bacteria and a brief outlook on future developments.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10074958&blobtype=pdf
Volume Number	2
DOI	10.1016/j.bbadva.2022.100065
PubMed Central reference number	PMC10074958
PubMed reference number	37082588
Journal	BBA Advances [BBA Adv]
e-ISSN	26671603
Language	English
Publisher	Elsevier
Publisher Date	2022-11-17
Access Restriction	Open
Rights License	© 2022 The Author(s)
Subject Keyword	Phosphoglycolipid antibiotics Bacterial cell wall Streptomyces Peptidoglycan glycosyltransferases Biosynthetic gene clusters
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biophysics