Endocrine late effects in survivors of infantile acute lymphoblastic leukemia.

Content Provider	Europe PMC
Author	Akisada, Hiroko Hasegawa, Mari Ishihara, Takashi Akisada, Naohiro Ochi, Satoshi Nogami, Keiji
Copyright Year	2023
Abstract	Abstract.Infantile acute lymphoblastic leukemia (ALL) is a rare disease. In survivors, endocrinelate effects, such as growth disorder and hypothyroidism, have been reported, but gonadalfunction remains unclear. Infantile ALL frequently requires transplantation and higherdoses of alkylating agents, even in the absence of transplantation. Some studies inchildhood cancer survivors reported that a cyclophosphamide equivalent dose (CED) of >20 g/m2 was associated with testosterone deficiency in boys and > 8g/m2 with ovarian dysfunction in girls. We retrospectively reviewed thetreatment and endocrine function of 6 infantile ALL survivors treated at our hospitalusing their medical records. The patients’ age at the time of the study was between 12 and26 yr. One patient had 0 transplant, four of them had 1 transplant, and one had 2transplants, with CEDs of 3, 9–11, and 24 g/m2 respectively. Two patients hadshort stature, and two patients experienced hypothyroidism. All three girls with a CED of9–11 g/m2 had primary hypogonadism, and the boy with a CED of 24g/m2 had high LH and FSH levels, suggesting testosterone deficiency andspermatogenesis disorders. In conclusion, gonadal function, growth and thyroid functionshould be carefully monitored in infantile ALL, and CED may be useful for predicting thedevelopment of hypogonadism.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10068619&blobtype=pdf
ISSN	09185739
Journal	Clinical Pediatric Endocrinology [Clin Pediatr Endocrinol]
Volume Number	32
DOI	10.1297/cpe.2022-0037
PubMed Central reference number	PMC10068619
Issue Number	2
PubMed reference number	37020698
e-ISSN	13477358
Language	English
Publisher	The Japanese Society for Pediatric Endocrinology
Publisher Date	2023-02-03
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the CreativeCommons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0:http://creativecommons.org/licenses/by-nc-nd/4.0/). 2023©The Japanese Society for PediatricEndocrinology
Subject Keyword	childhood cancer survivors cyclophosphamide equivalent dose endocrine late effects hypogonadism infantile acute lymphoblastic leukemia
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health