NDLI: The Role of Probiotics in Inflammation Associated with Major Surgery: A Narrative Review.

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The Role of Probiotics in Inflammation Associated with Major Surgery: A Narrative Review.

Content Provider	Europe PMC
Author	Matzaras, Rafail Anagnostou, Nikolaos Nikopoulou, Anna Tsiakas, Ilias Christaki, Eirini
Editor	Kotzampassi, Katerina
Copyright Year	2023
Abstract	Background: Gut microbiota is well-known for its ability to maintain intestinal homeostasis. However, the disruption of this homeostasis, known as dysbiosis, leads to multiple consequences, including local and systemic inflammation. Surgery-induced inflammation is a major concern for patients, as it leads to many infectious and non-infectious complications. Objective: The purpose of this review was to explore the role of probiotics and symbiotics in surgery-induced inflammation and to determine if their use is effective in combatting inflammation and its complications Methods and Materials: A literature search was conducted, and articles published only in English, until December 2022 were included. The results are reported in the form of a narrative review. Results: The perioperative use of probiotics and/or symbiotics results in lower risk of infectious complications, including reduced rates of surgical site infections, respiratory and urinary tract infections, shorter hospital stays, and fewer days of antibiotic administration. It also contributes to reducing non-infectious complications, as it mitigates systemic and local inflammation via maintenance of the intestinal barrier, improves intestinal mobility, and is associated with lower rates of postoperative pain and anastomotic leak. Conclusions: Restoring gut microbiota after disruptions caused by surgery may accelerate local healing processes, attenuate systemic inflammation, and may thus prove beneficial to certain populations.
Journal	Nutrients
Volume Number	15
PubMed Central reference number	PMC10059922
Issue Number	6
PubMed reference number	36986061
e-ISSN	20726643
DOI	10.3390/nu15061331
Language	English
Publisher	MDPI
Publisher Date	2023-03-08
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	microbiota gut microbiota inflammation surgery dysbiosis probiotics symbiotics
Content Type	Text
Resource Type	Article
Subject	Food Science Nutrition and Dietetics

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