Synthesis of 5,6-Dihydrophenanthridines via Palladium-Catalyzed Intramolecular Dehydrogenative Coupling of Two Aryl C-H Bonds.

Content Provider	Europe PMC
Author	Wang, Meng-Yue Zhu, Xue-Qing Zhao, Bao-Yin Zhang, Hong-Xia Wang, Yong-Qiang Jia, Qiong
Editor	Peng, Yu
Copyright Year	2023
Abstract	5,6-Dihydrophenanthridines are common aza heterocycle frameworks of natural products and pharmaceuticals. Herein, we reported the first palladium-catalyzed intramolecular C-H/C-H dehydrogenative coupling reaction of two simple arenes to generate 5,6-dihydrophenanthridines. The approach features a broad substrate scope and good tolerance of functional groups, offering an efficient alternative synthesis route for important 5,6-dihydrophenanthridine compounds.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28062498
PubMed Central reference number	PMC10055664
Issue Number	6
PubMed reference number	36985470
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-03-09
Access Restriction	Open
Subject Keyword	5,6-dihydrophenanthridines dehydrogenative coupling palladium catalysis C−H bond activation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry