New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture.

Content Provider	Europe PMC
Author	Epure, Alexandra Pârvu, Alina E. Vlase, Laurian Benedec, Daniela Hanganu, Daniela Oniga, Ovidiu Vlase, Ana-Maria Ielciu, Irina Toiu, Anca Oniga, Ilioara
Editor	Pelinescu, Diana Roxana
Copyright Year	2023
Abstract	The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of Taraxacum officinale tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that T. officinale could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress.
Volume Number	16
PubMed Central reference number	PMC10053582
Issue Number	3
PubMed reference number	36986458
Journal	Pharmaceuticals (Basel)
e-ISSN	14248247
DOI	10.3390/ph16030358
Language	English
Publisher	MDPI
Publisher Date	2023-02-26
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	Taraxacum officinale cardioprotective anti-inflammatory antioxidant polyphenols cichoric acid
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science Molecular Medicine