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German Cardiac Arrest Registry: rationale and design of G-CAR.
| Content Provider | Europe PMC |
|---|---|
| Author | Pöss, Janine Sinning, Christoph Schreiner, Isabelle Apfelbacher, Christian Drewitz, Karl-Philipp Hösler, Nadine Schneider, Steffen Pieske, Burkert Böttiger, Bernd W. Ewen, Sebastian Wienbergen, Harm Kelm, Malte Bock, Daniel Graf, Tobias Adler, Christoph Dutzmann, Jochen Knie, Wulf Orban, Martin Zeymer, Uwe Michels, Guido Thiele, Holger the G-CAR Investigators |
| Abstract | BackgroundIn Germany, 70,000–100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted.Study designThe German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged.ConclusionG-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment.Trial registryNCT05142124.Graphical abstractGerman Cardiac Arrest Registry (G-CAR) |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10050030&blobtype=pdf |
| ISSN | 18610684 |
| Journal | Clinical Research in Cardiology [Clin Res Cardiol] |
| Volume Number | 112 |
| DOI | 10.1007/s00392-022-02044-9 |
| PubMed Central reference number | PMC10050030 |
| Issue Number | 4 |
| PubMed reference number | 35729429 |
| e-ISSN | 18610692 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2022-06-21 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Cardiopulmonary resuscitation (CPR) Out-of-hospital cardiac arrest (OHCA) Registry Extracorporeal cardiopulmonary resuscitation (eCPR) Cardiac arrest centre (CAC) Post-resuscitation care |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
