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The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota.
| Content Provider | Europe PMC |
|---|---|
| Author | Scarano, Aurelia Laddomada, Barbara Blando, Federica De Santis, Stefania Verna, Giulio Chieppa, Marcello Santino, Angelo |
| Editor | Ciofi Baffoni, Simone |
| Copyright Year | 2023 |
| Abstract | In the past decades, many studies have widely examined the effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and for their chelating abilities, by which they can be potentially employed in cases of pathological conditions, such as iron overload. In this review, we have highlighted the chelating abilities of polyphenols, which are due to their structural specific sites, and the differences for each class of polyphenols. We have also explored how the dietary polyphenols and their iron-binding abilities can be important in inflammatory/immunomodulatory responses, with a special focus on the involvement of macrophages and dendritic cells, and how they might contribute to reshape the gut microbiota into a healthy profile. This review also provides evidence that the axes “polyphenol–iron metabolism–inflammatory responses” and “polyphenol–iron availability–gut microbiota” have not been very well explored so far, and the need for further investigation to exploit such a potential to prevent or counteract pathological conditions. |
| Journal | Antioxidants (Basel, Switzerland) |
| Volume Number | 12 |
| PubMed Central reference number | PMC10045931 |
| Issue Number | 3 |
| PubMed reference number | 36978878 |
| e-ISSN | 20763921 |
| DOI | 10.3390/antiox12030630 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-03-03 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | polyphenols iron metabolism inflammation gut microbiota |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Cell Biology Molecular Biology Physiology Clinical Biochemistry Food Science |
