NDLI: Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing.

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Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing.

Content Provider	Europe PMC
Author	Renò, Filippo Sabbatini, Maurizio
Editor	Costantini, Erica
Copyright Year	2023
Abstract	The lymphatic system is of fundamental importance in maintaining a fluid balance in the body and tissue homeostasis; it drains protein-rich lymph from the interstitial space and facilitates the release of cells that mediate the immune response. When one tissue is damaged, more cells and tissues work to repair the damaged site. Blood and lymph vessels are particularly important for tissue regeneration and healing. Angiogenesis is the process of the formation of new blood vessels and is induced by angiogenic factors such as VEGF-A; VEGF-C/D-induced lymphangiogenesis and both occur simultaneously during wound healing. After the inflammatory phase, lymphatic vessels suppress inflammation by aiding in the drainage of inflammatory mediators; thus, disorders of the lymphatic system often result in chronic and disabling conditions. It has recently been clarified that delayed wound healing, as in diabetes, can occur as a consequence of impaired lymphangiogenesis. In this review, we have highlighted recent advances in understanding the biology underlying lymphangiogenesis and its key role in wound healing, and the possibility of its pharmacological modulation as a novel therapeutic strategy for the treatment of chronic wounds.
Journal	Biomedicines
Volume Number	11
PubMed Central reference number	PMC10045303
Issue Number	3
PubMed reference number	36979635
e-ISSN	22279059
DOI	10.3390/biomedicines11030656
Language	English
Publisher	MDPI
Publisher Date	2023-02-21
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	lymphangiogenesis wound healing VEGF-A VEGF-C/D VEGFR-3
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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