Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria.

Content Provider	Europe PMC
Author	Sun, Jing Li, Mengfei Zhu, Qianshen Jia, Yuanyuan Tian, Jia Zhang, Chao Du, Xuanyi
Copyright Year	2023
Abstract	ObjectiveTo explore the predictive value of the proportion of glomerulosclerosis (GS) incidences on the progression of membranous nephropathy with non-nephrotic proteinuria (NNP).MethodsThis study was a single-center, retrospective, cohort study. Patients with biopsy-proven idiopathic membranous nephropathy were divided into three groups based on the proportion of glomerular sclerosis, and their demographic, clinical, and pathological data were compared. The proportions of primary and secondary endpoints were recorded, and the relationship between GS and primary outcomes (progression to nephrotic syndrome, complete remission, and persistent NNP) and the renal composite endpoint was analyzed.ResultsA total of 112 patients were divided into three groups according to the proportions of glomerulosclerosis. The median follow-up time was 26.5 (13–51) months. There were significant differences in blood pressure (p < 0.01), renal interstitial lesions (p < 0.0001), and primary endpoints (p = 0.005). The survival analysis showed that prognosis was significantly worse in patients with a high proportion of GS than in those patients with a middle and low proportion of GS (p < 0.001). The Cox multivariate analysis showed that after adjusting for age, sex, BP, 24-h urinary protein, serum creatinine, treatment scheme, and pathological factors, the risk of renal composite outcome in the low proportion group was 0.076 times higher than that in the high proportion group (p = 0.009, HR = 0.076, 95% CI: 0.011–0.532).ConclusionA high level of glomerulosclerosis was an independent risk factor for the prognosis of patients with membranous nephropathy with non-nephrotic proteinuria.
Page Count	8
ISSN	0886022X
Journal	Renal Failure
Volume Number	45
PubMed Central reference number	PMC10044162
Issue Number	1
PubMed reference number	36967636
e-ISSN	15256049
DOI	10.1080/0886022X.2023.2188088
Language	English
Publisher	Taylor & Francis
Publisher Date	2023-12-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject Keyword	Membranous nephropathy non-nephrotic proteinuria glomerulosclerosis risk factor renal composite endpoint
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine Nephrology