A molecular network map of orexin-orexin receptor signaling system.

Content Provider	Europe PMC
Author	Chatterjee, Oishi Gopalakrishnan, Lathika Pullimamidi, Deepshika Raj, Chinmayi Yelamanchi, Soujanya Gangadharappa, Bhavya Somaplara Nair, Bipin Mahadevan, Anita Raju, Rajesh Keshava Prasad, T. S.
Abstract	Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of HCRTR1 and HCRTR2, G-protein-coupled receptors of rhodopsin family and the endogenous ligands processed from HCRT pro-hormone, Orexin A and Orexin B. These neuropeptides are biosynthesized by the orexin neurons present in the lateral hypothalamus area, with dense projections to other brain regions. The orexin-receptor signaling is implicated in various metabolic as well as neurological disorders, making it a promising target for pharmacological interventions. However, there is limited information available on the collective representation of the signal transduction pathways pertaining to the orexin-orexin receptor signaling system. Here, we depict a compendium of the Orexin A/B stimulated reactions in the form of a basic signaling pathway map. This map catalogs the reactions into five categories: molecular association, activation/inhibition, catalysis, transport, and gene regulation. A total of 318 downstream molecules were annotated adhering to the guidelines of NetPath curation. This pathway map can be utilized for further assessment of signaling events associated with orexin-mediated physiological functions and is freely available on WikiPathways, an open-source pathway database (https://www.wikipathways.org/index.php/Pathway:WP5094). Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12079-022-00700-3.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10030760&blobtype=pdf
ISSN	18739601
Volume Number	17
DOI	10.1007/s12079-022-00700-3
PubMed Central reference number	PMC10030760
Issue Number	1
PubMed reference number	36480100
Journal	Journal of Cell Communication and Signaling [J Cell Commun Signal]
e-ISSN	1873961X
Language	English
Publisher	Springer Netherlands
Publisher Date	2022-12-08
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© The International CCN Society 2022
Subject Keyword	Orexin PathVisio Sleep Feeding Hypothalamus Signaling pathway
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry