Effectiveness of quadrivalent HPV vaccination in reducing vaccine-type and nonvaccine-type high risk HPV infection.

Content Provider	Europe PMC
Author	Li, Chenxi Hall, Thomas G. Hall, John J. He, Wen-Qiang
Copyright Year	2023
Abstract	This study aimed to assess human papillomavirus (HPV) vaccine effectiveness (VE) against both vaccine-type and nonvaccine-type high-risk HPV (hrHPV) infection, and duration of protection in United States. The study population was female participants aged 18–35 years with an HPV vaccination history and genital testing for HPV from the National Health and Nutrition Examination Survey, 2007–2016. Participants vaccinated before sexual debut were assessed against 13 nonvaccine-type hrHPV infection including 31/33/35/39/45/51/52/56/58/59/68/73/82. Multivariable logistic regression was used to estimate VE overall, by age at diagnosis, time since vaccination and lifetime sexual partners. A total of 3866 women were included in the analysis, with 23.3% (95% CI 21.3%–25.4%) having been vaccinated (≥1 dose). VE against vaccine-type HPV18/16/11/6 infection was 58% overall, which was mainly driven by those aged 18–22 years (VE = 64%) and 23–27 years (65%). Among participants aged 18–22 years vaccinated before sexual debut, the VE was 47% (23%–64%) against 13 nonvaccine-type hrHPV and 61% (95% CI 36%–77%) against 5 selected nonvaccine-type hrHPV35/39/52/58/59. Both direct effectiveness and cross-protection maintained effective for 5–10 years post vaccination. We also found the prevalence of ever diagnosed cervical cancer among vaccinated was significantly lower (0.46%, 4/874) than that among unvaccinated participants (1.27%, 38/2992). These findings highlight the potential of significant reduction of cervical cancer following the universal HPV vaccination programme.
Page Count	9
ISSN	09502688
Journal	Epidemiology and Infection
Volume Number	151
PubMed Central reference number	PMC10028998
PubMed reference number	36789960
e-ISSN	14694409
DOI	10.1017/S0950268823000213
Language	English
Publisher	Cambridge University Press
Publisher Date	2023-02-15
Publisher Place	Cambridge, UK
Access Restriction	Open
Rights License	This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. © The Author(s) 2023
Subject Keyword	cross protection human papillomavirus nonvaccine type high-risk HPV quadrivalent vaccine vaccine effectiveness vaccine type HPV
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Epidemiology