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Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes.
| Content Provider | Europe PMC |
|---|---|
| Author | Jin, Chen Wu, Yayu Zhang, Haipeng Xu, Bai Liu, Wenbin Ji, Chunnan Li, Panpan Chen, Zhenni Chen, Bing Li, Jiayin Wu, Xianming Jiang, Peipei Hu, Yali Xiao, Zhifeng Zhao, Yannan Dai, Jianwu |
| Abstract | AbstractNeural progenitor cell (NPC) transplantation is a promising approach for repairing spinal cord injury (SCI). However, cell survival, maturation and integration after transplantation are still major challenges. Here, we produced a novel centimeter‐scale human spinal cord neural tissue (hscNT) construct with human spinal cord neural progenitor cells (hscNPCs) and human spinal cord astrocytes (hscAS) on a linearly ordered collagen scaffold (LOCS). The hscAS promoted hscNPC adhesion, survival and neurite outgrowth on the LOCS, to form a linearly ordered spinal cord‐like structure consisting of mature neurons and glia cells. When transplanted into rats with SCI, the hscNT created a favorable microenvironment by inhibiting inflammation and glial scar formation, and promoted neural and vascular regeneration. Notably, the hscNT promoted neural circuit reconstruction and motor functional recovery. Engineered human spinal cord implants containing astrocytes and neurons assembled on axon guidance scaffolds may therefore have potential in the treatment of SCI. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10013752&blobtype=pdf |
| Page Count | 17 |
| Journal | Bioengineering & Translational Medicine [Bioeng Transl Med] |
| Volume Number | 8 |
| DOI | 10.1002/btm2.10448 |
| PubMed Central reference number | PMC10013752 |
| Issue Number | 2 |
| PubMed reference number | 36925694 |
| e-ISSN | 23806761 |
| Language | English |
| Publisher | John Wiley & Sons, Inc. |
| Publisher Date | 2022-11-09 |
| Publisher Place | Hoboken, USA |
| Access Restriction | Open |
| Rights License | This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. |
| Subject Keyword | human spinal cord astrocytes human spinal cord neural progenitor cells spinal cord injury tissue engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology Pharmaceutical Science Biomedical Engineering |
