RUNX2 promotes the suppression of osteoblast function and enhancement of osteoclast activity by multiple myeloma cells.

Content Provider	Europe PMC
Author	Huang, Beihui Liu, Huixin Chan, Szehoi Liu, Junru Gu, Jingli Chen, Meilan Kuang, Lifen Li, Xiaozhe Zhang, Xingding Li, Juan
Abstract	RUNX2 is a transcription factor that participates in osteoblast differentiation and chondrocyte maturation and plays an important role in the invasion and metastasis of cancers. With the deepening of research, evidence has indicated the correlation between RUNX2 and bone destruction in cancers. However, the mechanisms underlying its role in multiple myeloma remain unclear. By observing the induction effects of conditioned medium from myeloma cells on preosteoblasts (MC3T3-E1) and preosteoclasts (RAW264.7) and constructing myeloma-bearing mice, we found that RUNX2 promotes bone destruction in multiple myeloma. In vitro, conditioned medium from RUNX2-overexpressing myeloma cells reduced osteoblast activity and increased osteoclast activity. In vivo, RUNX2 expression was positively correlated with bone loss in myeloma-bearing mice. These results suggest that therapeutic inhibition of RUNX2 may protect against bone destruction by maintaining the balance between osteoblast and osteoclast activity in multiple myeloma.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10006269&blobtype=pdf
ISSN	13570560
Journal	Medical Oncology (Northwood, London, England) [Med Oncol]
Volume Number	40
DOI	10.1007/s12032-023-01960-8
PubMed Central reference number	PMC10006269
Issue Number	4
PubMed reference number	36897488
e-ISSN	1559131X
Language	English
Publisher	Springer US
Publisher Date	2023-03-10
Publisher Place	New York
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2023
Subject Keyword	RUNX2 Multiple myeloma Bone destruction Osteoblast Osteoclast
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology